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China’s inhalable Covid vaccine taken as a booster shot may boost antibodies 300 times

The inhalable Covid-19 vaccine developed by CanSino Biologics in China showed a 250-300-fold increase in neutralizing antibody levels as a booster shot, the media reported. According to the latest laboratory study by a Chinese pharmaceutical company, the aerosolized inhaled adenovirus type 5 vector-based Covid-19 vaccine (Ad5-nCoV) taken after completing two doses of inactivated vaccine for half a year is safe. The Global Times has reported that it is significantly more immunogenic than boosted inactivated vaccines.

In contrast, he added that boosting the inactivated vaccine after two doses of the inactivated vaccine increased the neutralizing antibody by only 30-fold.

The study suggests a heterogeneous (mix-match vaccine regimen) prime boost regimen that increases the breadth, intensity, and duration of the immune response over the same (same vaccine regimen) booster shot, the report said. ..

Zhu Tao, co-founder and chief scientific officer of CanSino BIO, cited a previous study conducted in Turkey. Compared to booster immunization of inactivated vaccines.

Similar clinical trials were conducted by US researchers in a heterologous booster shot regimen using three approved vaccines: one adenovirus-based vaccine by Johnson & Johnson and two mRNA vaccines by Moderna and Pfizer. The results showed that heterologous regimens boost immunity.

Allogeneic boosters increased neutralizing antibody titers 4.2 to 20-fold, while heterologous boosters increased titers 6.2-76-fold, a recently published study report on preprint server medRvix is ​​still peer-reviewed. He said it meant no.

So far, at least 13 provinces and regions in China, including Anhui, Fujian and Hubei in central China, have launched programs to boost residents’ immunity to Covid-19, the report said. increase.

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China’s inhalable Covid vaccine taken as a booster shot may boost antibodies 300 times

Source link China’s inhalable Covid vaccine taken as a booster shot may boost antibodies 300 times

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